CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
4 | Few Secondary Structures |
|
4.10 | Irregular |
|
4.10.1280 | Metalloproteases ("zincins"), catalytic domain fold |
|
4.10.1280.10 | Clostridium neurotoxins |
Domain Context
CATH Clusters
| Superfamily | Clostridium neurotoxins |
| Functional Family | Botulinum neurotoxin type A |
Enzyme Information
| 3.4.24.69 |
Bontoxilysin.
based on mapping to UniProt P0DPI1
Limited hydrolysis of proteins of the neuroexocytosis apparatus, synaptobrevins, SNAP25 or syntaxin. No detected action on small molecule substrates.
-!- Belongs to peptidase family M27.
|
UniProtKB Entries (1)
| P0DPI1 |
BXA1_CLOBH
Clostridium botulinum A str. Hall
Botulinum neurotoxin type A
|
PDB Structure
| PDB | 3K3Q |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
A Single-Domain Llama Antibody Potently Inhibits the Enzymatic Activity of Botulinum Neurotoxin by Binding to the Non-Catalytic alpha-Exosite Binding Region.
J.Mol.Biol.
|