CATH Classification

Domain Context

CATH Clusters

Superfamily 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Functional Family 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

Enzyme Information

4.6.1.12
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase.
based on mapping to UniProt Q3JRA0
2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl- D-erythritol 2,4-cyclodiphosphate + CMP.
-!- Forms part of an alternative nonmevalonate pathway for terpenoid biosynthesis.

UniProtKB Entries (1)

Q3JRA0
ISPF_BURP1
Burkholderia pseudomallei 1710b
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

PDB Structure

PDB 3K14
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Leveraging structure determination with fragment screening for infectious disease drug targets: MECP synthase from Burkholderia pseudomallei.
Begley, D.W., Hartley, R.C., Davies, D.R., Edwards, T.E., Leonard, J.T., Abendroth, J., Burris, C.A., Bhandari, J., Myler, P.J., Staker, B.L., Stewart, L.J.
J Struct Funct Genomics
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