CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.605 | Aldehyde Dehydrogenase; Chain A, domain 1 |
|
3.40.605.10 | Aldehyde Dehydrogenase; Chain A, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Aldehyde Dehydrogenase; Chain A, domain 1 |
| Functional Family | Succinate-semialdehyde dehydrogenase I |
Enzyme Information
| 1.2.1.- |
With NAD(+) or NADP(+) as acceptor.
based on mapping to UniProt P25526
|
| 1.2.1.79 |
Succinate-semialdehyde dehydrogenase (NADP(+)).
based on mapping to UniProt P25526
Succinate semialdehyde + NADP(+) + H(2)O = succinate + NADPH.
-!- This enzyme participates in the degradation of glutamate and 4-aminobutyrate. -!- It is similar to EC 1.2.1.24 and EC 1.2.1.16 but is specific for NADP(+). -!- The enzyme from Escherichia coli is 20-fold more active with NADP(+) than NAD(+).
|
UniProtKB Entries (1)
| P25526 |
GABD_ECOLI
Escherichia coli K-12
Succinate-semialdehyde dehydrogenase [NADP(+)] GabD
|
PDB Structure
| PDB | 3JZ4 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The X-ray crystal structure of Escherichia coli succinic semialdehyde dehydrogenase; structural insights into NADP+/enzyme interactions.
Plos One
|
