CATH Domain 3jsuA02

CATH Classification

Level	CATH Code	Description
	6	Special
	6.10	Helix non-globular
	6.10.250	Single alpha-helices involved in coiled-coils or other helix-helix interfaces
	6.10.250.2210

Domain Context

CATH Clusters

Superfamily	6.10.250.2210
Functional Family

Enzyme Information

UniProtKB Entries (1)

D9N170_PLAFA

Plasmodium falciparum

Bifunctional dihydrofolate reductase-thymidylate synthase

PDB Structure

PDB	3JSU
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate Nzila, A., Rottmann, M., Chitnumsub, P., Kiara, S.M., Kamchonwongpaisan, S., Maneeruttanarungroj, C., Taweechai, S., Yeung, B.K., Goh, A., Lakshminarayana, S.B., Zou, B., Wong, J., Ma, N.L., Weaver, M., Keller, T.H., Dartois, V., Wittlin, S., Brun, R., Yuthavong, Y., Diagana, T.T. Antimicrob.Agents Chemother.