CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.430 | Dihydrofolate Reductase, subunit A | |
3.40.430.10 | Dihydrofolate Reductase, subunit A |
Domain Context
CATH Clusters
Superfamily | Dihydrofolate Reductase, subunit A |
Functional Family | Bifunctional dihydrofolate reductase-thymidylate synthase |
Enzyme Information
UniProtKB Entries (1)
D9N170 |
D9N170_PLAFA
Plasmodium falciparum
Bifunctional dihydrofolate reductase-thymidylate synthase
|
PDB Structure
PDB | 3JSU |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Preclinical evaluation of the antifolate QN254, 5-chloro- N'6'-(2,5-dimethoxy-benzyl)-quinazoline-2,4,6-triamine, as an antimalarial drug candidate
Antimicrob.Agents Chemother.
|