CATH Domain 3jsbB02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.70	Alpha-Beta Plaits
	3.30.70.2640	Arenavirus RNA polymerase

Domain Context

CATH Clusters

Superfamily	Arenavirus RNA polymerase
Functional Family	RNA-directed RNA polymerase L

Enzyme Information

2.7.7.48	RNA-directed RNA polymerase. based on mapping to UniProt P14240 Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). -!- Catalyzes RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- See also EC 2.7.7.6.
3.1.-.-	Acting on ester bonds. based on mapping to UniProt P14240

UniProtKB Entries (1)

L_LYCVA

Lymphocytic choriomeningitis virus (strain Armstrong)

RNA-directed RNA polymerase L

PDB Structure

PDB	3JSB
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	The N-terminal domain of the arenavirus L protein is an RNA endonuclease essential in mRNA transcription Morin, B., Coutard, B., Lelke, M., Ferron, F.P., Kerber, R., Jamal, S., Frangeul, A., Baronti, C., Charrel, R., de Lamballerie, X., Vonrhein, C., Lescar, J., Bricogne, G., Gunther, S., Canard, B. Plos Pathog.