CATH Domain 3jpnA03

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.460	Beta Polymerase; domain 2
	3.30.460.10	Beta Polymerase, domain 2

Domain Context

CATH Clusters

Superfamily	Beta Polymerase, domain 2
Functional Family	DNA polymerase beta

Enzyme Information

2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt P06746 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
4.2.99.-	Other carbon-oxygen lyases. based on mapping to UniProt P06746

UniProtKB Entries (1)

DPOLB_HUMAN

Homo sapiens

DNA polymerase beta

PDB Structure

PDB	3JPN
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Halogenated beta,gamma-Methylene- and Ethylidene-dGTP-DNA Ternary Complexes with DNA Polymerase beta: Structural Evidence for Stereospecific Binding of the Fluoromethylene Analogues. Batra, V.K., Pedersen, L.C., Beard, W.A., Wilson, S.H., Kashemirov, B.A., Upton, T.G., Goodman, M.F., McKenna, C.E. J.Am.Chem.Soc.