CATH Classification
Domain Context
CATH Clusters
| Superfamily | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Functional Family | Phosphodiesterase |
Enzyme Information
| 3.1.4.17 |
3',5'-cyclic-nucleotide phosphodiesterase.
based on mapping to UniProt O00408
Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate.
-!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
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UniProtKB Entries (1)
| O00408 |
PDE2A_HUMAN
Homo sapiens
CGMP-dependent 3',5'-cyclic phosphodiesterase
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PDB Structure
| PDB | 3ITM |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct.
Proc.Natl.Acad.Sci.USA
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