CATH Domain 3imxA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.420	Nucleotidyltransferase; domain 5
	3.30.420.40	ATPase, nucleotide binding domain

Domain Context

CATH Clusters

Superfamily	3.30.420.40
Functional Family	Phosphotransferase

Enzyme Information

2.7.1.2

Glucokinase.

based on mapping to UniProt P35557

ATP + D-glucose = ADP + D-glucose 6-phosphate.

-!- A group of enzymes found in invertebrates and microorganisms highly specific for glucose.

UniProtKB Entries (1)

HXK4_HUMAN

Homo sapiens

Glucokinase

PDB Structure

PDB	3IMX
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Investigation of functionally liver selective glucokinase activators for the treatment of type 2 diabetes. Bebernitz, G.R., Beaulieu, V., Dale, B.A., Deacon, R., Duttaroy, A., Gao, J., Grondine, M.S., Gupta, R.C., Kakmak, M., Kavana, M., Kirman, L.C., Liang, J., Maniara, W.M., Munshi, S., Nadkarni, S.S., Schuster, H.F., Stams, T., St Denny, I., Taslimi, P.M., Vash, B., Caplan, S.L. J.Med.Chem.