CATH Classification
Level | CATH Code | Description |
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3 | Alpha Beta |
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3.30 | 2-Layer Sandwich |
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3.30.420 | Nucleotidyltransferase; domain 5 |
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3.30.420.390 |
Domain Context
CATH Clusters
Superfamily | 3.30.420.390 |
Functional Family | DNA polymerase gamma, catalytic subunit |
Enzyme Information
2.7.7.7 |
DNA-directed DNA polymerase.
based on mapping to UniProt P54098
Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.
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UniProtKB Entries (1)
P54098 |
DPOG1_HUMAN
Homo sapiens
DNA polymerase subunit gamma-1
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PDB Structure
PDB | 3IKM |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural insight into processive human mitochondrial DNA synthesis and disease-related polymerase mutations.
Cell(Cambridge,Mass.)
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