CATH Domain 3ijiA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.390	Enolase-like; domain 1
	3.30.390.10	Enolase-like, N-terminal domain

Domain Context

CATH Clusters

Superfamily	Enolase-like, N-terminal domain
Functional Family	Hydrophobic dipeptide epimerase

Enzyme Information

5.1.1.20

L-Ala-D/L-Glu epimerase.

based on mapping to UniProt Q8A861

L-alanyl-D-glutamate = L-alanyl-L-glutamate.

-!- The enzyme, characterized from the bacteria Escherichia coli and Bacillus subtilis, is involved in the recycling of the murein peptide, of which L-Ala-D-Glu is a component. -!- In vitro the enzyme from E.coli epimerizes several L-Ala-L-X dipeptides with broader specificity than the enzyme from B.subtilis. -!- Formerly EC 5.1.1.n1.

UniProtKB Entries (1)

Q8A861

AEEP_BACTN

Bacteroides thetaiotaomicron VPI-5482

L-Ala-D/L-Glu epimerase

PDB Structure

PDB	3IJI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily. Lukk, T., Sakai, A., Kalyanaraman, C., Brown, S.D., Imker, H.J., Song, L., Fedorov, A.A., Fedorov, E.V., Toro, R., Hillerich, B., Seidel, R., Patskovsky, Y., Vetting, M.W., Nair, S.K., Babbitt, P.C., Almo, S.C., Gerlt, J.A., Jacobson, M.P. Proc.Natl.Acad.Sci.USA