CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.30 | Glutaredoxin |
|
3.40.30.120 |
Domain Context
CATH Clusters
| Superfamily | 3.40.30.120 |
| Functional Family | Aklavinone 12-hydroxylase RdmE |
Enzyme Information
| 1.14.13.180 |
Aklavinone 12-hydroxylase.
based on mapping to UniProt Q54530
Aklavinone + NADPH + O(2) = epsilon-rhodomycinone + NADP(+) + H(2)O.
-!- The enzymes from the Gram-positive bacteria Streptomyces peucetius and Streptomyces purpurascens participate in the biosynthesis of daunorubicin, doxorubicin and rhodomycins.
|
UniProtKB Entries (1)
| Q54530 |
DNRF_STREF
Streptomyces purpurascens
Aklavinone 12-hydroxylase RdmE
|
PDB Structure
| PDB | 3IHG |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural basis for substrate recognition and specificity in aklavinone-11-hydroxylase from rhodomycin biosynthesis.
J.Mol.Biol.
|