CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.20 | Up-down Bundle |
|
1.20.910 | Heme Oxygenase; Chain A |
|
1.20.910.10 | Heme oxygenase-like |
Domain Context
CATH Clusters
| Superfamily | Heme oxygenase-like |
| Functional Family | Aminopyrimidine aminohydrolase |
Enzyme Information
| 3.5.99.2 |
Aminopyrimidine aminohydrolase.
based on mapping to UniProt A8KRL3
(1) 4-amino-5-aminomethyl-2-methylpyrimidine + H(2)O = 4-amino-5- hydroxymethyl-2-methylpyrimidine + ammonia. (2) Thiamine + H(2)O = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole.
-!- Previously known as thiaminase II, this enzyme is involved in the regeneration of the thiamine pyrimidine from degraded products, rather than in thiamine degradation, and participates in thiamine salvage pathways.
|
UniProtKB Entries (1)
| A8KRL3 |
TENA_HELPX
Helicobacter pylori
Aminopyrimidine aminohydrolase
|
PDB Structure
| PDB | 3IBX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural and mutational analysis of TenA protein (HP1287) from the Helicobacter pylori thiamin salvage pathway - evidence of a different substrate specificity.
Febs J.
|
