CATH Domain 3i7iA00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.390	Collagenase (Catalytic Domain)
	3.40.390.10	Collagenase (Catalytic Domain)

Domain Context

CATH Clusters

Superfamily	Collagenase (Catalytic Domain)
Functional Family	Collagenase 3

Enzyme Information

3.4.24.-

Metalloendopeptidases.

based on mapping to UniProt P45452

UniProtKB Entries (1)

MMP13_HUMAN

Homo sapiens

Collagenase 3

PDB Structure

PDB	3I7I
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Improving potency and selectivity of a new class of non-Zn-chelating MMP-13 inhibitors. Heim-Riether, A., Taylor, S.J., Liang, S., Gao, D.A., Xiong, Z., Michael August, E., Collins, B.K., Farmer, B.T., Haverty, K., Hill-Drzewi, M., Junker, H.D., Mariana Margarit, S., Moss, N., Neumann, T., Proudfoot, J.R., Keenan, L.S., Sekul, R., Zhang, Q., Li, J., Farrow, N.A. Bioorg.Med.Chem.Lett.