1 keywords

CATH Domain 3i2iA02

CATH Classification

Level CATH Code Description
Class 1 Mainly Alpha
Architecture 1.10 Orthogonal Bundle
Topology 1.10.3020 alpha-amino acid ester hydrolase ( Helical cap domain)
Homologous Superfamily 1.10.3020.10 alpha-amino acid ester hydrolase ( Helical cap domain)

Domain Context

CATH Clusters

Superfamily alpha-amino acid ester hydrolase ( Helical cap domain)
Functional Family

Enzyme Information

3.1.1.84
Cocaine esterase.
based on mapping to UniProt Q9L9D7
Cocaine + H(2)O = ecgonine methyl ester + benzoate.
-!- Rhodococcus sp. strain MB1 and Pseudomonas maltophilia strain MB11L can utilize cocaine as sole source of carbon and energy.

UniProtKB Entries (1)

Q9L9D7
COCE_RHOSM
Rhodococcus sp. MB1 'Bresler 1999'
Cocaine esterase

PDB Structure

PDB 3I2I
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural analysis of thermostabilizing mutations of cocaine esterase.
Narasimhan, D., Nance, M.R., Gao, D., Ko, M.C., Macdonald, J., Tamburi, P., Yoon, D., Landry, D.M., Woods, J.H., Zhan, C.G., Tesmer, J.J., Sunahara, R.K.
Protein Eng.Des.Sel.