CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.75 | 5-stranded Propeller |
|
3.75.10 | L-arginine/glycine Amidinotransferase; Chain A |
|
3.75.10.10 | L-arginine/glycine Amidinotransferase; Chain A |
Domain Context
CATH Clusters
| Superfamily | L-arginine/glycine Amidinotransferase; Chain A |
| Functional Family | N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 |
Enzyme Information
| 3.5.3.18 |
Dimethylargininase.
based on mapping to UniProt O94760
N(omega),N(omega)-dimethyl-L-arginine + H(2)O = dimethylamine + L-citrulline.
-!- Also acts on N(omega)-methyl-L-arginine.
|
UniProtKB Entries (1)
| O94760 |
DDAH1_HUMAN
Homo sapiens
N(G),N(G)-dimethylarginine dimethylaminohydrolase 1
|
PDB Structure
| PDB | 3I2E |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Developing dual and specific inhibitors of dimethylarginine dimethylaminohydrolase-1 and nitric oxide synthase: toward a targeted polypharmacology to control nitric oxide.
Biochemistry
|
