CATH Domain 3hw8A04

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.210	Beta Polymerase; domain 3
	3.30.210.10	DNA polymerase, thumb domain

Domain Context

CATH Clusters

Superfamily	DNA polymerase, thumb domain
Functional Family	DNA polymerase lambda

Enzyme Information

4.2.99.-	Other carbon-oxygen lyases. based on mapping to UniProt Q9UGP5
2.7.7.7	DNA-directed DNA polymerase. based on mapping to UniProt Q9UGP5 Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). -!- Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. -!- Cannot initiate a chain de novo. -!- Requires a primer which may be DNA or RNA. -!- See also EC 2.7.7.49.

UniProtKB Entries (1)

DPOLL_HUMAN

Homo sapiens

DNA polymerase lambda

PDB Structure

PDB	3HW8
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Scrunching Durning DNA Repair Synthesis Garcia-Diaz, M., Bebenek, K., Larrea, A.A., Havener, J.M., Perera, L., Krahn, J.M., Pedersen, L.C., Ramsden, D.A., Kunkel, T.A. To be Published