CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.365 | Aldehyde Oxidoreductase; domain 4 |
|
3.30.365.10 | Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain |
Domain Context
CATH Clusters
| Superfamily | Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain |
| Functional Family | Nicotinate dehydrogenase medium molybdopterin subunit |
Enzyme Information
| 1.17.1.5 |
Nicotinate dehydrogenase.
based on mapping to UniProt Q0QLF1
Nicotinate + H(2)O + NADP(+) = 6-hydroxynicotinate + NADPH.
-!- The enzyme is capable of acting on a variety of nicotinate analogs to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3- dicarboxylate, trigonelline and 6-methylnicotinate. -!- The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide. -!- Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. -!- Other enzymes involved in this pathway are EC 1.3.7.1, EC 3.5.2.18, EC 1.1.1.291, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32. -!- Formerly EC 1.5.1.13.
|
UniProtKB Entries (1)
| Q0QLF2 |
NDLMS_EUBBA
Eubacterium barkeri
Nicotinate dehydrogenase large molybdopterin subunit
|
PDB Structure
| PDB | 3HRD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
The Mo-Se active site of nicotinate dehydrogenase
Proc.Natl.Acad.Sci.USA
|
