CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.365 | Aldehyde Oxidoreductase; domain 4 | |
3.30.365.10 | Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain |
Domain Context
CATH Clusters
Superfamily | Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain |
Functional Family |
Enzyme Information
1.17.1.5 |
Nicotinate dehydrogenase.
based on mapping to UniProt Q0QLF1
Nicotinate + H(2)O + NADP(+) = 6-hydroxynicotinate + NADPH.
-!- The enzyme is capable of acting on a variety of nicotinate analogs to varying degrees, including pyrazine-2-carboxylate, pyrazine 2,3- dicarboxylate, trigonelline and 6-methylnicotinate. -!- The enzyme from Clostridium barkeri also possesses a catalytically essential, labile selenium that can be removed by reaction with cyanide. -!- Forms part of the nicotinate-fermentation catabolism pathway in Eubacterium barkeri. -!- Other enzymes involved in this pathway are EC 1.3.7.1, EC 3.5.2.18, EC 1.1.1.291, EC 5.4.99.4, EC 5.3.3.6, EC 4.2.1.85 and EC 4.1.3.32. -!- Formerly EC 1.5.1.13.
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UniProtKB Entries (1)
Q0QLF2 |
NDLMS_EUBBA
Eubacterium barkeri
Nicotinate dehydrogenase large molybdopterin subunit
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PDB Structure
PDB | 3HRD |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
The Mo-Se active site of nicotinate dehydrogenase
Proc.Natl.Acad.Sci.USA
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