CATH Domain 3hr1A00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase 10A

Enzyme Information

3.1.4.17	3',5'-cyclic-nucleotide phosphodiesterase. based on mapping to UniProt Q9QYJ6 Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate. -!- Acts on 3',5'-cyclic AMP, 3',5'-cyclic dAMP, 3',5'-cyclic IMP, 3',5'-cyclic GMP and 3',5'-cyclic CMP.
3.1.4.35	3',5'-cyclic-GMP phosphodiesterase. based on mapping to UniProt Q9QYJ6 Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

UniProtKB Entries (1)

PDE10_RAT

Rattus norvegicus

CAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

PDB Structure

PDB	3HR1
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia Verhoest, P.R., Chapin, D.S., Corman, M., Fonseca, K., Harms, J.F., Hou, X., Marr, E.S., Menniti, F.S., Nelson, F., O'Connor, R., Pandit, J., Proulx-Lafrance, C., Schmidt, A.W., Schmidt, C.J., Suiciak, J.A., Liras, S. J.Med.Chem.