CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.90 | Alpha-Beta Complex | |
3.90.1110 | Dna-directed Rna Polymerase Ii 140kd Polypeptide; Chain: B; domain 3 | |
3.90.1110.10 | RNA polymerase Rpb2, domain 2 |
Domain Context
CATH Clusters
Superfamily | RNA polymerase Rpb2, domain 2 |
Functional Family | DNA-directed RNA polymerase subunit beta |
Enzyme Information
2.7.7.6 |
DNA-directed RNA polymerase.
based on mapping to UniProt P08518
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.
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UniProtKB Entries (1)
P20433 |
RPB4_YEAST
Saccharomyces cerevisiae S288C
DNA-directed RNA polymerase II subunit RPB4
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PDB Structure
PDB | 3HOV |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Structural basis of transcription: mismatch-specific fidelity mechanisms and paused RNA polymerase II with frayed RNA.
Mol.Cell
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