CATH Domain 3hocA01

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.418	Actin-binding Protein, T-fimbrin; domain 1
	1.10.418.10	Calponin-like domain

Domain Context

CATH Clusters

Superfamily	Calponin-like domain
Functional Family	Filamin-B isoform A

Enzyme Information

UniProtKB Entries (1)

FLNA_HUMAN

Homo sapiens

Filamin-A

PDB Structure

PDB	3HOC
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Skeletal dysplasias due to filamin A mutations result from a gain-of-function mechanism distinct from allelic neurological disorders Clark, A.R., Sawyer, G.M., Robertson, S.P., Sutherland-Smith, A.J. Hum.Mol.Genet.