CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
2 | Mainly Beta |
|
2.40 | Beta Barrel |
|
2.40.10 | Thrombin, subunit H |
|
2.40.10.10 | Trypsin-like serine proteases |
Domain Context
CATH Clusters
| Superfamily | Trypsin-like serine proteases |
| Functional Family | Prothrombin |
Enzyme Information
| 3.4.21.5 |
Thrombin.
based on mapping to UniProt P19221
Selective cleavage of Arg-|-Gly bonds in fibrinogen to form fibrin and release fibrinopeptides A and B.
-!- More selective than trypsin and plasmin. -!- Belongs to peptidase family S1. -!- Formerly EC 3.4.4.13.
|
UniProtKB Entries (2)
| P19221 |
THRB_MOUSE
Mus musculus
Prothrombin
|
| P25116 |
PAR1_HUMAN
Homo sapiens
Proteinase-activated receptor 1
|
PDB Structure
| PDB | 3HKI |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mechanism of the Anticoagulant Activity of Thrombin Mutant W215A/E217A.
J.Biol.Chem.
|
