CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.800 | Phenylalanine Hydroxylase |
|
1.10.800.10 | Aromatic amino acid hydroxylase |
Domain Context
CATH Clusters
| Superfamily | Aromatic amino acid hydroxylase |
| Functional Family | tryptophan 5-hydroxylase 1 |
Enzyme Information
| 1.14.16.4 |
Tryptophan 5-monooxygenase.
based on mapping to UniProt P17752
L-tryptophan + tetrahydrobiopterin + O(2) = 5-hydroxy-L-tryptophan + 4a-hydroxytetrahydrobiopterin.
-!- Activated by phosphorylation, catalyzed by a Ca(2+)-activated protein kinase. -!- The 4a-hydroxytetrahydrobiopterin formed can dehydrate to 6,7- dihydrobiopterin, both spontaneously and by the action of EC 4.2.1.96. -!- The 6,7-dihydrobiopterin can be enzymically reduced back to tetrahydrobiopterin, by EC 1.5.1.34, or slowly rearranges into the more stable compound 7,8-dihydrobiopterin.
|
UniProtKB Entries (1)
| P17752 |
TPH1_HUMAN
Homo sapiens
Tryptophan 5-hydroxylase 1
|
PDB Structure
| PDB | 3HFB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Mechanism of Inhibition of Novel Tryptophan Hydroxylase Inhibitors Revealed by Co-crystal Structures and Kinetic Analysis.
Curr Chem Genomics
|