CATH Domain 3hdzA00

CATH Classification

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.1300	Catalytic domain of cyclic nucleotide phosphodiesterase 4b2b
	1.10.1300.10	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain

Domain Context

CATH Clusters

Superfamily	3'5'-cyclic nucleotide phosphodiesterase, catalytic domain
Functional Family	Phosphodiesterase

Enzyme Information

3.1.4.35

3',5'-cyclic-GMP phosphodiesterase.

based on mapping to UniProt O76074

Guanosine 3',5'-cyclic phosphate + H(2)O = guanosine 5'-phosphate.

3.1.4.53

3',5'-cyclic-AMP phosphodiesterase.

based on mapping to UniProt P27815

Adenosine 3',5'-cyclic phosphate + H(2)O = adenosine 5'-phosphate.

-!- Specific for 3',5'-cAMP and does not hydrolyze other nucleoside 3',5'-cyclic phosphates such as cGMP (cf. EC 3.1.4.17 and EC 3.1.4.35). -!- It is involved in modulation of the levels of cAMP, which is a mediator in the processes of cell transformation and proliferation. -!- Formerly EC 3.1.4.n1.

UniProtKB Entries (1)

O76074

PDE5A_HUMAN

Homo sapiens

CGMP-specific 3',5'-cyclic phosphodiesterase

PDB Structure

PDB	3HDZ
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors. Owen, D.R., Walker, J.K., Jon Jacobsen, E., Freskos, J.N., Hughes, R.O., Brown, D.L., Bell, A.S., Brown, D.G., Phillips, C., Mischke, B.V., Molyneaux, J.M., Fobian, Y.M., Heasley, S.E., Moon, J.B., Stallings, W.C., Joseph Rogier, D., Fox, D.N., Palmer, M.J., Ringer, T., Rodriquez-Lens, M., Cubbage, J.W., Blevis-Bal, R.M., Benson, A.G., Acker, B.A., Maddux, T.M., Tollefson, M.B., Bond, B.R., Macinnes, A., Yu, Y. Bioorg.Med.Chem.Lett.