CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.572 | Thymidylate Synthase; Chain A |
|
3.30.572.10 | Thymidylate synthase/dCMP hydroxymethylase domain |
Domain Context
CATH Clusters
| Superfamily | Thymidylate synthase/dCMP hydroxymethylase domain |
| Functional Family |
Enzyme Information
| 2.1.1.45 |
Thymidylate synthase.
based on mapping to UniProt Q27793
5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP.
|
| 1.5.1.3 |
Dihydrofolate reductase.
based on mapping to UniProt Q27793
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.
|
UniProtKB Entries (1)
| Q27793 |
DRTS_TRYCR
Trypanosoma cruzi
Bifunctional dihydrofolate reductase-thymidylate synthase
|
PDB Structure
| PDB | 3HBB |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structures of dihydrofolate reductase-thymidylate synthase of Trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate.
Acta Crystallogr.,Sect.D
|
