CATH Domain 3h81A02

Level	CATH Code	Description
	1	Mainly Alpha
	1.10	Orthogonal Bundle
	1.10.12	Lyase 2-enoyl-coa Hydratase; Chain A, domain 2
	1.10.12.10	Lyase 2-enoyl-coa Hydratase, Chain A, domain 2

Superfamily	Lyase 2-enoyl-coa Hydratase, Chain A, domain 2
Functional Family	Probable enoyl-CoA hydratase, mitochondrial

4.2.1.17

Enoyl-CoA hydratase.

based on mapping to UniProt P9WNN9

(3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H(2)O.

-!- Acts in the reverse direction. -!- With cis-compounds, yields (3R)-3-hydroxyacyl-CoA (cf. EC 4.2.1.74).

ECHA8_MYCTU

Mycobacterium tuberculosis H37Rv

Probable enoyl-CoA hydratase echA8

PDB	3H81
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Increasing the structural coverage of tuberculosis drug targets. Baugh, L., Phan, I., Begley, D.W., Clifton, M.C., Armour, B., Dranow, D.M., Taylor, B.M., Muruthi, M.M., Abendroth, J., Fairman, J.W., Fox, D., Dieterich, S.H., Staker, B.L., Gardberg, A.S., Choi, R., Hewitt, S.N., Napuli, A.J., Myers, J., Barrett, L.K., Zhang, Y., Ferrell, M., Mundt, E., Thompkins, K., Tran, N., Lyons-Abbott, S., Abramov, A., Sekar, A., Serbzhinskiy, D., Lorimer, D., Buchko, G.W., Stacy, R., Stewart, L.J., Edwards, T.E., Van Voorhis, W.C., Myler, P.J. Tuberculosis (Edinb)