CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.47 | Peroxisomal Thiolase; Chain A, domain 1 |
|
3.40.47.10 | Thiolase/Chalcone synthase |
Domain Context
CATH Clusters
| Superfamily | 3.40.47.10 |
| Functional Family | Anthraniloyl-CoA anthraniloyltransferase |
Enzyme Information
| 2.3.1.262 |
Anthraniloyl-CoA anthraniloyltransferase.
based on mapping to UniProt P20582
Anthraniloyl-CoA + malonyl-CoA = 2-aminobenzoylacetyl-CoA + CoA + CO(2).
-!- The enzyme, characterized from the bacterium Pseudomonas aeruginosa, participates in the synthesis of the secondary metabolites 2-heptyl- 3-hydroxy-4(1H)-quinolone and 4-hydroxy-2(1H)-quinolone. -!- The enzyme transfers an anthraniloyl group from anthraniloyl-CoA to an internal L-cysteine residue, followed by its transfer to malonyl- CoA to produce a short-lived product that can cyclize spontaneously to form 4-hydroxy-2(1H)-quinolone. -!- However, when EC 3.1.2.32 is present, it removes the CoA moiety from the product, forming the stable 2-aminobenzoylacetate.
|
UniProtKB Entries (1)
| P20582 |
PQSD_PSEAE
Pseudomonas aeruginosa PAO1
Anthraniloyl-CoA anthraniloyltransferase
|
PDB Structure
| PDB | 3H77 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structure of PqsD, a Pseudomonas quinolone signal biosynthetic enzyme, in complex with anthranilate.
Biochemistry
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