CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.70 | Cathepsin B; Chain A |
|
3.90.70.10 | Cysteine proteinases |
Domain Context
CATH Clusters
| Superfamily | Cysteine proteinases |
| Functional Family | Cathepsin S |
Enzyme Information
| 3.4.22.43 |
Cathepsin V.
based on mapping to UniProt O60911
The recombinant enzyme hydrolyzes proteins (serum albumin, collagen) and synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val- Arg-NHMec).
-!- Maximally active at pH 5.7 and unstable at neutral pH. -!- Compound E-64, leupeptin and chicken cystatin are inhibitors. -!- Belongs to peptidase family C1.
|
UniProtKB Entries (2)
| O60911 |
CATL2_HUMAN
Homo sapiens
Cathepsin L2
|
| Q3Y9I6 |
CLIT5_CLINE
Clitocybe nebularis
Clitocypin-5
|
PDB Structure
| PDB | 3H6S |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Versatile loops in mycocypins inhibit three protease families.
J.Biol.Chem.
|
