CATH Domain 3h5qA02

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.1030	Pyrimidine Nucleoside Phosphorylase; Chain A, domain 2
	3.40.1030.10	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain

Domain Context

CATH Clusters

Superfamily	Nucleoside phosphorylase/phosphoribosyltransferase catalytic domain
Functional Family	Pyrimidine-nucleoside phosphorylase

Enzyme Information

2.4.2.2

Pyrimidine-nucleoside phosphorylase.

based on mapping to UniProt Q5HE64

(1) Uridine + phosphate = uracil + alpha-D-ribose 1-phosphate. (2) Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. (3) 2'-deoxyuridine + phosphate = uracil + 2-deoxy-alpha-D-ribose 1-phosphate.

-!- Unlike EC 2.4.2.3 and EC 2.4.2.4, this enzyme can accept both the ribonucleoside uridine and the 2'-deoxyribonucleosides 2'-deoxyuridine and thymidine. -!- The reaction is reversible, and the enzyme does not distinguish between alpha-D-ribose 1-phosphate and 2-deoxy-alpha-D-ribose 1-phosphate in the synthetic direction. -!- Formerly EC 2.4.2.23.

UniProtKB Entries (1)

Q5HE64

PDP_STAAC

Staphylococcus aureus subsp. aureus COL

Pyrimidine-nucleoside phosphorylase

PDB Structure

PDB	3H5Q
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of a putative pyrimidine-nucleoside phosphorylase from Staphylococcus aureus Shumilin, I.A., Zimmerman, M., Cymborowski, M., Skarina, T., Onopriyenko, O., Anderson, W.F., Savchenko, A., Minor, W., Center for Structural Genomics of Infectious Diseases (CSGID) TO BE PUBLISHED