CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.30 | 2-Layer Sandwich |
|
3.30.160 | Double Stranded RNA Binding Domain |
|
3.30.160.280 |
Domain Context
CATH Clusters
| Superfamily | 3.30.160.280 |
| Functional Family |
Enzyme Information
| 3.4.21.72 |
IgA-specific serine endopeptidase.
based on mapping to UniProt P44969
Cleavage of immunoglobulin A molecules at certain Pro-|-Xaa bonds in the hinge region. No small molecule substrates are known.
-!- Species variants differing slightly in specificity are secreted by Gram-negative bacteria Neisseria gonorrhoeae and Haemophilus influenzae. -!- Some other bacterial endopeptidases with similar specificity are of metallotype (see EC 3.4.24.13). -!- Belongs to peptidase family S6.
|
UniProtKB Entries (1)
| P44969 |
IGA0_HAEIN
Haemophilus influenzae Rd KW20
Immunoglobulin A1 protease autotransporter
|
PDB Structure
| PDB | 3H09 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Active-Site Gating Regulates Substrate Selectivity in a Chymotrypsin-Like Serine Protease The Structure of Haemophilus influenzae Immunoglobulin A1 Protease.
J.Mol.Biol.
|