CATH Classification
Domain Context
CATH Clusters
| Superfamily | Naphthalene 1,2-dioxygenase Alpha Subunit; Chain A, domain 1 |
| Functional Family |
Enzyme Information
| 1.14.12.18 |
Biphenyl 2,3-dioxygenase.
based on mapping to UniProt Q46372
Biphenyl + NADH + O(2) = (1S,2R)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD(+).
-!- The enzyme from Burkholderia fungorum strain LB400 (previously Pseudomonas sp.) is part of a multicomponent system composed of an NADH:ferredoxin oxidoreductase (FAD cofactor), a [2Fe-2S] Rieske-type ferredoxin, and a terminal oxygenase that contains a [2Fe-2S] Rieske- type iron-sulfur cluster and a catalytic mononuclear nonheme iron center. -!- Chlorine-substituted biphenyls can also act as substrates. -!- Similar to the three-component enzyme systems EC 1.14.12.3 and EC 1.14.12.11.
|
UniProtKB Entries (1)
| Q46373 |
BPHE_COMTE
Comamonas testosteroni
Biphenyl dioxygenase subunit beta
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PDB Structure
| PDB | 3GZX |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural Characterization of Pandoraea pnomenusa B-356 Biphenyl Dioxygenase Reveals Features of Potent Polychlorinated Biphenyl-Degrading Enzymes
Plos One
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