1 keywords

CATH Domain 3gw5B01

CATH Classification

Level CATH Code Description
Class 2 Mainly Beta
Architecture 2.40 Beta Barrel
Topology 2.40.70 Cathepsin D, subunit A; domain 1
Homologous Superfamily 2.40.70.10 Acid Proteases

Domain Context

CATH Clusters

Superfamily Acid Proteases
Functional Family renin

Enzyme Information

3.4.23.15
Renin.
based on mapping to UniProt P00797
Cleavage of Leu-|-Xaa bond in angiotensinogen to generate angiotensin I.
-!- Belongs to peptidase family A1. -!- Formerly EC 3.4.4.15 and EC 3.4.99.19.

UniProtKB Entries (1)

P00797
RENI_HUMAN
Homo sapiens
Renin

PDB Structure

PDB 3GW5
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Design and optimization of renin inhibitors: Orally bioavailable alkyl amines.
Tice, C.M., Xu, Z., Yuan, J., Simpson, R.D., Cacatian, S.T., Flaherty, P.T., Zhao, W., Guo, J., Ishchenko, A., Singh, S.B., Wu, Z., Scott, B.B., Bukhtiyarov, Y., Berbaum, J., Mason, J., Panemangalore, R., Cappiello, M.G., Muller, D., Harrison, R.K., McGeehan, G.M., Dillard, L.W., Baldwin, J.J., Claremon, D.A.
Bioorg.Med.Chem.Lett.