CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.30 | 2-Layer Sandwich | |
3.30.465 | Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase; domain 3 | |
3.30.465.10 |
Domain Context
CATH Clusters
Superfamily | 3.30.465.10 |
Functional Family |
Enzyme Information
1.21.3.3 |
Reticuline oxidase.
based on mapping to UniProt P30986
(S)-reticuline + O(2) = (S)-scoulerine + H(2)O(2).
-!- Acts on (S)-reticuline and related compounds, converting the N-methyl group into the methylene bridge ('berberine bridge') of (S)- tetrahydroprotoberberines. -!- The product of the reaction, (S)-scoulerine, is a precursor of protopine, protoberberine and benzophenanthridine alkaloid biosynthesis in plants. -!- Formerly EC 1.5.3.9.
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UniProtKB Entries (1)
P30986 |
RETO_ESCCA
Eschscholzia californica
Reticuline oxidase
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PDB Structure
PDB | 3GSY |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Berberine bridge enzyme catalyzes the six electron oxidation of (S)-reticuline to dehydroscoulerine.
Phytochemistry
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