CATH Domain 3gmdC00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	Corticosteroid 11-beta-dehydrogenase isozyme 1

Enzyme Information

1.1.1.146

11-beta-hydroxysteroid dehydrogenase.

based on mapping to UniProt P50172

An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.

UniProtKB Entries (1)

DHI1_MOUSE

Mus musculus

Corticosteroid 11-beta-dehydrogenase isozyme 1

PDB Structure

PDB	3GMD
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11 beta-hydroxysteroid dehydrogenase type I. Valeur, E., Christmann-Franck, S., Lepifre, F., Carniato, D., Cravo, D., Charon, C., Bozec, S., Musil, D., Hillertz, P., Doare, L., Schmidlin, F., Lecomte, M., Schultz, M., Roche, D. Bioorg.Med.Chem.Lett.