CATH Domain 3gg6A00

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.79	Nucleoside Triphosphate Pyrophosphohydrolase
	3.90.79.10	Nucleoside Triphosphate Pyrophosphohydrolase

Domain Context

CATH Clusters

Superfamily	Nucleoside Triphosphate Pyrophosphohydrolase
Functional Family	8-oxo-dGDP phosphatase NUDT18

Enzyme Information

3.6.1.58

8-oxo-dGDP phosphatase.

based on mapping to UniProt Q6ZVK8

8-oxo-dGDP + H(2)O = 8-oxo-dGMP + phosphate.

-!- The enzyme catalyzes the hydrolysis of both 8-oxo-dGDP and 8-oxo-GDP thereby preventing translational errors caused by oxidative damage. -!- The preferred in vivo substrate is not known. -!- The enzyme does not degrade 8-oxo-dGTP and 8-oxo-GTP to the monophosphates (cf. EC 3.6.1.55). -!- Ribonucleotide diphosphates and deoxyribonucleotide diphosphates are hydrolyzed with broad specificity. -!- The bifunctional enzyme NUDT5 also hydrolyzes ADP-ribose to AMP and D-ribose 5-phosphate (cf. EC 3.6.1.13). -!- The human enzyme NUDT18 also hydrolyzes 8-oxo-dADP and 2-hydroxy- dADP, the latter at a slower rate.

UniProtKB Entries (1)

Q6ZVK8

NUD18_HUMAN

Homo sapiens

8-oxo-dGDP phosphatase NUDT18

PDB Structure

PDB	3GG6
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Crystal structure of the NUDIX domain of human NUDT18 Tresaugues, L., Siponen, M.I., Lehtio, L., Arrowsmith, C.H., Berglund, H., Bountra, C., Collins, R., Dahlgren, L.G., Edwards, A.M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Johansson, A., Johansson, I., Karlberg, T., Kotenyova, T., Moche, M., Nilsson, M.E., Nyman, T., Persson, C., Sagemark, J., Schueler, H., Thorsell, A.G., Van Den Berg, S., Weigelt, J., Welin, M., Wisniewska, M., Nordlund, P. To be Published