CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.109 | NADH Oxidase |
|
3.40.109.10 | NADH Oxidase |
Domain Context
CATH Clusters
| Superfamily | NADH Oxidase |
| Functional Family | Iodotyrosine deiodinase 1 |
Enzyme Information
| 1.21.1.1 |
Iodotyrosine deiodinase.
based on mapping to UniProt Q9DCX8
L-tyrosine + 2 NADP(+) + 2 iodide = 3,5-diiodo-L-tyrosine + 2 NADPH.
-!- The enzyme activity has only been demonstrated in the direction of 3-deiodination. -!- Formerly EC 1.22.1.1.
|
UniProtKB Entries (1)
| Q9DCX8 |
IYD1_MOUSE
Mus musculus
Iodotyrosine deiodinase 1
|
PDB Structure
| PDB | 3GFD |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of iodotyrosine deiodinase, a novel flavoprotein responsible for iodide salvage in thyroid glands.
J.Biol.Chem.
|
