CATH Classification

Domain Context

CATH Clusters

Superfamily Jelly Rolls
Functional Family

Enzyme Information

1.13.11.72
2-hydroxyethylphosphonate dioxygenase.
based on mapping to UniProt Q5IW40
2-hydroxyethylphosphonate + O(2) = hydroxymethylphosphonate + formate.
-!- Isolated from some bacteria including Streptomyces hygroscopicus and Streptomyces viridochromogenes. -!- The pro-R hydrogen at C-2 of the ethyl group is retained by the formate ion. -!- Any stereochemistry at C-1 of the ethyl group is lost. -!- One atom from dioxygen is present in each product. -!- Involved in phosphinothricin biosynthesis.

UniProtKB Entries (1)

Q5IW40
HEPD_STRVT
Streptomyces viridochromogenes DSM 40736
2-hydroxyethylphosphonate dioxygenase

PDB Structure

PDB 3GBF
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
An Unusual Carbon-Carbon Bond Cleavage Reaction in the Biosynthesis of the Herbicide Phosphinothricin
Cicchillio, R.M., Zhang, H., Blodgett, J.A.V., Whitteck, J.T., Li, G., Nair, S.K., van der Donk, W.A., Metcalf, W.W.
To be Published
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