CATH Classification

Domain Context

CATH Clusters

Superfamily Nucleotide cyclase
Functional Family Adenylate cyclase

Enzyme Information

4.6.1.1
Adenylate cyclase.
based on mapping to UniProt P26769
ATP = 3',5'-cyclic AMP + diphosphate.
-!- Also acts on dATP to form 3',5'-cyclic dAMP. -!- Requires pyruvate. -!- Activated by NAD(+) in presence of EC 2.4.2.31.

UniProtKB Entries (3)

P26769
ADCY2_RAT
Rattus norvegicus
Adenylate cyclase type 2
P30803
ADCY5_CANLF
Canis lupus familiaris
Adenylate cyclase type 5
P04896
GNAS2_BOVIN
Bos taurus
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

PDB Structure

PDB 3G82
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
2',3'-(O)-(N-Methyl)anthraniloyl-inosine 5'-triphosphate is the Most Potent Adenylyl Cyclase 1 and 5 Inhibitor Known so far and Effectively Promotes Catalytic Subunit Assembly in the Absence of Forskolin
Huebner, M., Geduhn, J., Pinto, C., Mou, T.-C., Konig, B., Sprang, S.R., Seifert, R.
To be Published
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