CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.40 | 3-Layer(aba) Sandwich |
|
3.40.50 | Rossmann fold |
|
3.40.50.720 | NAD(P)-binding Rossmann-like Domain |
Domain Context
CATH Clusters
| Superfamily | NAD(P)-binding Rossmann-like Domain |
| Functional Family | Corticosteroid 11-beta-dehydrogenase isozyme 1 |
Enzyme Information
| 1.1.1.146 |
11-beta-hydroxysteroid dehydrogenase.
based on mapping to UniProt Q6QLL4
An 11-beta-hydroxysteroid + NADP(+) = an 11-oxosteroid + NADPH.
|
UniProtKB Entries (1)
| Q6QLL4 |
DHI1_CAVPO
Cavia porcellus
Corticosteroid 11-beta-dehydrogenase isozyme 1
|
PDB Structure
| PDB | 3G49 |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11beta-hydroxysteroid dehydrogenase type 1: Discovery of PF-915275.
Bioorg.Med.Chem.Lett.
|