CATH Domain 3g3eD01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.40	3-Layer(aba) Sandwich
	3.40.50	Rossmann fold
	3.40.50.720	NAD(P)-binding Rossmann-like Domain

Domain Context

CATH Clusters

Superfamily	NAD(P)-binding Rossmann-like Domain
Functional Family	D-amino-acid oxidase

Enzyme Information

1.4.3.3

D-amino-acid oxidase.

based on mapping to UniProt P14920

A D-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2).

-!- Wide specificity for D-amino acids. -!- Also acts on glycine.

UniProtKB Entries (1)

OXDA_HUMAN

Homo sapiens

D-amino-acid oxidase

PDB Structure

PDB	3G3E
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Discovery, SAR, and pharmacokinetics of a novel 3-Hydroxyquinolin-2(1H)-one series of potent D-amino acid oxidase (DAAO) inhibitors Duplantier, A.J., Becker, S.L., Bohanon, M.J., Borzilleri, K.A., Chrunyk, B.A., Downs, J.T., Hu, L.Y., El-Kattan, A., James, L.C., Liu, S., Lu, J., Maklad, N., Mansour, M.N., Mente, S., Piotrowski, M.A., Sakya, S.M., Sheehan, S., Steyn, S.J., Strick, C.A., Williams, V.A., Zhang, L. J.Med.Chem.