CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Dihydrofolate reductase

Enzyme Information

1.5.1.3
Dihydrofolate reductase.
based on mapping to UniProt P0A017
5,6,7,8-tetrahydrofolate + NADP(+) = 7,8-dihydrofolate + NADPH.
-!- The enzyme from animals and some micro-organisms also slowly reduces folate to 5,6,7,8-tetrahydrofolate. -!- Formerly EC 1.5.1.4.

UniProtKB Entries (1)

P0A017
DYR_STAAU
Staphylococcus aureus
Dihydrofolate reductase

PDB Structure

PDB 3FY9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Inhibitory properties and X-ray crystallographic study of the binding of AR-101, AR-102 and iclaprim in ternary complexes with NADPH and dihydrofolate reductase from Staphylococcus aureus
Oefner, C., Parisi, S., Schulz, H., Lociuro, S., Dale, G.E.
Acta Crystallogr.,Sect.D