CATH Classification

Domain Context

CATH Clusters

Superfamily Phosphatase 2C, C-terminal domain suprefamily
Functional Family Protein phosphatase, Mg2+/Mn2+ dependent 1A

Enzyme Information

3.1.3.16
Protein-serine/threonine phosphatase.
based on mapping to UniProt P35813
[a protein]-serine/threonine phosphate + H(2)O = [a protein]- serine/threonine + phosphate.
-!- A group of enzymes removing the serine- or threonine-bound phosphate group from a wide range of phosphoproteins, including a number of enzymes which have been phosphorylated under the action of a kinase (cf. EC 3.1.3.48). -!- The spleen enzyme also acts on phenolic phosphates and phosphamides (cf. EC 3.9.1.1).

UniProtKB Entries (1)

P35813
PPM1A_HUMAN
Homo sapiens
Protein phosphatase 1A

PDB Structure

PDB 3FXO
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Structural basis for the Mn2+-dependent activation of human PPM1A
Hu, T., Wang, L., Wang, K., Chen, J., Jiang, H., Shen, X.
To be published
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