CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
1 | Mainly Alpha |
|
1.10 | Orthogonal Bundle |
|
1.10.8 | Helicase, Ruva Protein; domain 3 |
|
1.10.8.100 | Ribosomal RNA adenine dimethylase-like, domain 2 |
Domain Context
CATH Clusters
| Superfamily | Ribosomal RNA adenine dimethylase-like, domain 2 |
| Functional Family |
Enzyme Information
| 2.1.1.182 |
16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase.
based on mapping to UniProt Q5SM60
4 S-adenosyl-L-methionine + adenine(1518)/adenine(1519) in 16S rRNA = 4 S-adenosyl-L-homocysteine + N(6)-dimethyladenine(1518)/N(6)- dimethyladenine(1519) in 16S rRNA.
-!- KsgA introduces the most highly conserved ribosomal RNA modification, the dimethylation of adenine(1518) and adenine(1519) in 16S rRNA. -!- Strains lacking the methylase are resistant to kasugamycin. -!- Formerly EC 2.1.1.48.
|
UniProtKB Entries (1)
| Q5SM60 |
RSMA_THET8
Thermus thermophilus HB8
Ribosomal RNA small subunit methyltransferase A
|
PDB Structure
| PDB | 3FUV |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Structural rearrangements in the active site of the Thermus thermophilus 16S rRNA methyltransferase KsgA in a binary complex with 5'-methylthioadenosine.
J.Mol.Biol.
|
