CATH Classification

Domain Context

CATH Clusters

Superfamily 3.20.20.220
Functional Family Methylenetetrahydrofolate reductase

Enzyme Information

1.5.1.20
Methylenetetrahydrofolate reductase (NAD(P)H).
based on mapping to UniProt P0AEZ1
5-methyltetrahydrofolate + NAD(P)(+) = 5,10-methylenetetrahydrofolate + NAD(P)H.
-!- Menadione can also serve as an electron acceptor. -!- Formerly EC 1.1.1.68, EC 1.1.1.171, EC 1.1.99.15 and EC 1.7.99.5.

UniProtKB Entries (1)

P0AEZ1
METF_ECOLI
Escherichia coli K-12
5,10-methylenetetrahydrofolate reductase

PDB Structure

PDB 3FST
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Functional role for the conformationally mobile phenylalanine 223 in the reaction of methylenetetrahydrofolate reductase from Escherichia coli.
Lee, M.N., Takawira, D., Nikolova, A.P., Ballou, D.P., Furtado, V.C., Phung, N.L., Still, B.R., Thorstad, M.K., Tanner, J.J., Trimmer, E.E.
Biochemistry
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