CATH Classification
| Level | CATH Code | Description |
|---|---|---|
|
3 | Alpha Beta |
|
3.90 | Alpha-Beta Complex |
|
3.90.1150 | Aspartate Aminotransferase, domain 1 |
|
3.90.1150.10 | Aspartate Aminotransferase, domain 1 |
Domain Context
CATH Clusters
| Superfamily | Aspartate Aminotransferase, domain 1 |
| Functional Family | Aspartate aminotransferase |
Enzyme Information
| 2.6.1.57 |
Aromatic-amino-acid transaminase.
based on mapping to UniProt P04693
An aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate.
-!- L-methionine can also act as donor, more slowly. -!- Oxaloacetate can act as acceptor. -!- Controlled proteolysis converts the enzyme to EC 2.6.1.1.
|
| 2.6.1.107 |
Beta-methylphenylalanine transaminase.
based on mapping to UniProt P04693
(2S,3S)-3-methylphenylalanine + 2-oxoglutarate = (3S)-2-oxo-3- phenylbutanoate + L-glutamate.
-!- Isolated from the bacterium Streptomyces hygroscopicus NRRL3085. -!- It is involved in the biosynthesis of the glycopeptide antibiotic mannopeptimycin.
|
UniProtKB Entries (1)
| P04693 |
TYRB_ECOLI
Escherichia coli K-12
Aromatic-amino-acid aminotransferase
|
PDB Structure
| PDB | 3FSL |
| External Links | |
| Method | X-RAY DIFFRACTION |
| Organism | |
| Primary Citation |
Crystal structure of tyrosine aminotransferase tripple mutant (P181Q,R183G,A321K) from Escherichia coli at 2.35 A resolution
To be Published
|