CATH Domain 3fofA01

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.90	Alpha-Beta Complex
	3.90.199	Topoisomerase II; domain 5
	3.90.199.10	Topoisomerase II, domain 5

Domain Context

CATH Clusters

Superfamily	Topoisomerase II, domain 5
Functional Family	DNA gyrase subunit A

Enzyme Information

5.6.2.3

DNA topoisomerase (ATP-hydrolyzing).

based on mapping to UniProt P72525

ATP-dependent breakage, passage and rejoining of double-stranded DNA.

-!- The enzyme can introduce negative superhelical turns into double- stranded circular DNA. -!- One unit has nicking-closing activity, and another catalyzes super- twisting and hydrolysis of ATP (cf. EC 5.6.2.2). -!- Formerly EC 5.99.1.3.

UniProtKB Entries (1)

P72525

PARC_STRPN

Streptococcus pneumoniae TIGR4

DNA topoisomerase 4 subunit A

PDB Structure

PDB	3FOF
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structural insight into the quinolone-DNA cleavage complex of type IIA topoisomerases Laponogov, I., Sohi, M.K., Veselkov, D.A., Pan, X.-S., Sawhney, R., Thompson, A.W., McAuley, K.E., Fisher, L.M., Sanderson, M.R. Nat.Struct.Mol.Biol.