CATH Domain 3fllA00

CATH Classification

Level	CATH Code	Description
	2	Mainly Beta
	2.40	Beta Barrel
	2.40.128	Lipocalin
	2.40.128.20	Calycin beta-barrel core domain

Domain Context

CATH Clusters

Superfamily	2.40.128.20
Functional Family

Enzyme Information

1.7.6.1

Nitrite dismutase.

based on mapping to UniProt Q94734

3 nitrite + 2 H(+) = 2 nitric oxide + nitrate + H(2)O.

-!- The enzyme is one of the nitrophorins from the salivary gland of the blood-feeding insect Rhodnius prolixus. -!- Nitric oxide produced induces vasodilation after injection. -!- Nitrophorins 2 and 4 can also catalyze this reaction.

UniProtKB Entries (1)

Q94734

NP4_RHOPR

Rhodnius prolixus

Nitrophorin-4

PDB Structure

PDB	3FLL
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Effect of mutation of carboxyl side-chain amino acids near the heme on the midpoint potentials and ligand binding constants of nitrophorin 2 and its NO, histamine, and imidazole complexes. Berry, R.E., Shokhirev, M.N., Ho, A.Y., Yang, F., Shokhireva, T.K., Zhang, H., Weichsel, A., Montfort, W.R., Walker, F.A. J.Am.Chem.Soc.