CATH Classification
Level | CATH Code | Description |
---|---|---|
3 | Alpha Beta | |
3.40 | 3-Layer(aba) Sandwich | |
3.40.430 | Dihydrofolate Reductase, subunit A | |
3.40.430.10 | Dihydrofolate Reductase, subunit A |
Domain Context
CATH Clusters
Superfamily | Dihydrofolate Reductase, subunit A |
Functional Family | Dihydrofolate reductase |
Enzyme Information
UniProtKB Entries (1)
Q81R22 |
Q81R22_BACAN
Bacillus anthracis
Dihydrofolate reductase
|
PDB Structure
PDB | 3FL9 |
External Links | |
Method | X-RAY DIFFRACTION |
Organism | |
Primary Citation |
Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity.
Antimicrob.Agents Chemother.
|