CATH Classification

Domain Context

CATH Clusters

Superfamily Dihydrofolate Reductase, subunit A
Functional Family Dihydrofolate reductase

Enzyme Information

UniProtKB Entries (1)

Q81R22
Q81R22_BACAN
Bacillus anthracis
Dihydrofolate reductase

PDB Structure

PDB 3FL9
External Links
Method X-RAY DIFFRACTION
Organism
Primary Citation
Crystal structure of Bacillus anthracis dihydrofolate reductase with the dihydrophthalazine-based trimethoprim derivative RAB1 provides a structural explanation of potency and selectivity.
Bourne, C.R., Bunce, R.A., Bourne, P.C., Berlin, K.D., Barrow, E.W., Barrow, W.W.
Antimicrob.Agents Chemother.