CATH Domain 3fkiA09

CATH Classification

Level	CATH Code	Description
	3	Alpha Beta
	3.30	2-Layer Sandwich
	3.30.1360	Gyrase A; domain 2
	3.30.1360.140

Domain Context

CATH Clusters

Superfamily	3.30.1360.140
Functional Family	DNA-directed RNA polymerase subunit

Enzyme Information

2.7.7.6

DNA-directed RNA polymerase.

based on mapping to UniProt P04050

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).

-!- Catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. -!- Can initiate a chain de novo. -!- In eukaryotes three forms of the enzyme have been distinguished on the basis of sensitivity of alpha-amanitin, and the type of RNA synthesized. -!- See also EC 2.7.7.19 and EC 2.7.7.48.

UniProtKB Entries (1)

P38902

RPB11_YEAST

Saccharomyces cerevisiae S288C

DNA-directed RNA polymerase II subunit RPB11

PDB Structure

PDB	3FKI
External Links	PDBSum Proteopedia
Method	X-RAY DIFFRACTION
Organism
Primary Citation	Structure of the 12-Subunit RNA Polymerase II Refined with the Aid of Anomalous Diffraction Data Meyer, P.A., Ye, P., Suh, M.H., Zhang, M., Fu, J. J.Biol.Chem.